Size
50µg
Catalog no#
PKSR030453-50µg
Price
376 EUR
Activity
NA
Fusion tag
C-6His
Accession
O35187
AP Mol Mass
38 kDa
Mol Mass
25.7 kDa
Tissue
lymphocyte
ExpressedHost
Human cells
Sequence
Vla30-Gln248
Group
recombinants
Latin name
Rattus norvegicus
Source
Recombinants or rec. proteins
Purity
＞95% as determined by reducing SDS-PAGE.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Synonym
T-lymphocyte activation antigen CD80; Activation B7-1 antigen; B7; CD80
Description
Antigens are peptides or recombinant or native dependent on the production method.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Stability and Storage
Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
Background
Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.