Size
50µg
Catalog no#
PKSH031476-50µg
Price
203 EUR
Activity
NA
Fusion tag
C-6His
Mol Mass
24.7 kDa
AP Mol Mass
38-60 kDa
Accession
NP_005182.1
Expressed Host
Human cells
Group
recombinants
Sequence
Val35-Asn242
Source
Recombinants or rec. proteins
Purity
＞95% as determined by reducing SDS-PAGE.
Reconstitution
Please refer to it for detailed information.
Endotoxin
＜1.0 EU per µg as determined by LAL test.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Description
Antigens are peptides or recombinant or native dependent on the production method.
Synonym
CD80; Activation B7-1 antigen; B7; BB1; CD28LG1; CD28LGB7-1 antigen; T-lymphocyte activation antigen CD80
Shipping
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
Stability and Storage
Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Background
Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. Studies have shown that CTLA-4 binds mostly to CD80. The structure presents two extracellular domains: a membrane distal variable-like domain (IgV) and a membrane proximal Ig constant-like domain (IgC) along with an intracellular domain. Both IgV and IgC consist of anti-parallel beta sandwiches joined by a short linker region. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.