Size

500ug

Catalog no#

GEN633460

Price

774 EUR

Concentration

N/A

Tissue

cell

Clone

10A3

Immunoglobulin isotype

IgG2b

Category

Antibodies

Clonality

Monoclonal

Also known as

CD4, Low Endotoxin

Subcategory

Mnoclonal antibodies

Source organism

Mouse (Mus musculus)

Host organism

Rat (Rattus norvegicus)

Form/Appearance

Supplied as a liquid in PBS.

Other gene names

CD4; CD4; CD4mut; CD4 receptor

Gene name synonims

CD4; CD4; CD4mut; CD4 receptor

Gene name

CD4; CD4; CD4mut; CD4 receptor

Purification method

Affinity Purified by Protein G affinity chromatography.

Tested applications:

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)

Other names

CD4; CD4 protein; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); OTTHUMP00000238897; T-cell surface antigen T4/Leu-3; CD4 molecule; N/A

Species reactivity

Mouse (Mus musculus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

Storage and shipping

Store the antibody at +4 degrees Celsius for short term storage.. Aliquot to avoid repeated freezing and thawing. For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 

Specificity and cross-reactivity

Recognizes mouse CD4 at ~55kD. Reported to block CD4+ T-cell activation. Blocks class II MHC antigen-specific binding, thereby inhibiting functions such as class II MHC antigen-specific proliferation and the release of lymphokines. May also be used for in vivo and in vitro cell depletion of CD4+ T-cells.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.

Description

The CD4, Endotoxin (CD4 Receptor, CD4mut, T Surface Antigen T4/Leu3, T Surface Glycoprotein CD4, L3T4, LY-4, Tac antigen, p55, IL 2 Receptor alpha, IL2Ra, T Growth Factor Receptor) is a α- or alpha protein sometimes glycoprotein present in blood.Antigens are peptides or recombinant or native dependent on the production method.CD4+ T helper cell marker or cluster differentiator of white blood cells in FACS or flow cytometry. Used offer coupled to magnetic beads. GENTAUR makes custom magnetic bead couplings on 50 and 250 nm beads for certain clones.For cells, cell lines and tissues in culture till half confluency.Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.